Wandering beyond small molecules: Peptides as allosteric protein modulators
M Mannes, C Martin, C Menet, S Ballet - Trends in Pharmacological …, 2022 - cell.com
Recent years have seen the rise of allosteric modulation as an innovative approach for drug
design and discovery, efforts which culminated in the development of several clinical …
design and discovery, efforts which culminated in the development of several clinical …
Urotensin II Receptor Modulation with 1, 3, 4-Benzotriazepin-2-one Tetrapeptide Mimics
X Wei, S Diarra, A Douchez… - Journal of Medicinal …, 2023 - ACS Publications
Urotensin II receptor (UT) modulators that differentiate the effects of the endogenous cyclic
peptide ligands urotensin II (UII) and urotensin II-related peptide (URP) offer potential for …
peptide ligands urotensin II (UII) and urotensin II-related peptide (URP) offer potential for …
Pepducin-mediated G protein-coupled receptor signaling in the cardiovascular system
H Xu, DG Tilley - Journal of cardiovascular pharmacology, 2022 - journals.lww.com
Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-
coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of …
coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of …
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new\b {eta}-arrestin inhibitor
RL Brouillette, CE Mona, M Desgagné… - arXiv preprint arXiv …, 2024 - arxiv.org
\b {eta}-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and
trafficking. To study their functional role in the regulation of specific receptor systems, current …
trafficking. To study their functional role in the regulation of specific receptor systems, current …
[PDF][PDF] Discovery, Design and Synthesis of G Protein Peptidomimetics
M Mannes - 2022 - researchportal.vub.be
The present thesis manuscript concludes my semi-industrial PhD fellowship in both the
fields of peptide synthesis in the Research Group of Organic Chemistry (ORGC), Faculty of …
fields of peptide synthesis in the Research Group of Organic Chemistry (ORGC), Faculty of …