Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is
defined by an integrated set of advanced and automated methods that analyze the …

Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …

Over the last several decades, researchers have time and again proposed use of non-
chromatographic methods for processing of biotherapeutic products. However …

Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …

Continuous processing has been garnering much interest lately for production of
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …

Combining process analytical technology (PAT) with continuous production provides a
powerful tool to observe and control monoclonal antibody (mAb) fermentation and …

Online monitoring of product quality attributes using high resolution analytical tools is a
prerequisite for implementation of process analytical technology (PAT) and thereby ensuring …

Quality by Design (QbD) is currently receiving increased attention from the pharmaceutical
community. As a result, most major biotech manufacturers are in varying stages of …

Liquid chromatography is considered to be the bottleneck for purification of therapeutic
proteins. Development and optimization of chromatography process is a cumbersome …

On‐line monitoring tools for downstream chromatographic processing (DSP) of
biotherapeutics can enable fast actions to correct for disturbances in the upstream, gain …