Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered …
L Tesfay, BT Paul, A Konstorum, Z Deng, AO Cox… - Cancer research, 2019 - AACR
Activation of ferroptosis, a recently described mechanism of regulated cell death, dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism …
F Röhrig, A Schulze - Nature reviews cancer, 2016 - nature.com
Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis …
NA di Meo, F Lasorsa, M Rutigliano… - Expert Review of …, 2023 - Taylor & Francis
Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial macromolecules involved in a wide range of metabolic pathways. The increased …
Cancer cells are often exposed to a metabolically challenging environment with scarce availability of oxygen and nutrients. This metabolic stress leads to changes in the balance …
K Vriens, S Christen, S Parik, D Broekaert… - Nature, 2019 - nature.com
Most tumours have an aberrantly activated lipid metabolism, that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only …
F Baenke, B Peck, H Miess… - Disease models & …, 2013 - journals.biologists.com
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of …
M Schütte, T Risch, N Abdavi-Azar, K Boehnke… - Nature …, 2017 - nature.com
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease …
Solid tumors typically develop hostile microenvironments characterized by irregular vascularization and poor oxygen (O 2) and nutrient supply. Whereas normal cells modulate …