The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline

J Melrose - Antioxidants, 2023 - mdpi.com
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …

[HTML][HTML] Current understanding of glucose transporter 4 expression and functional mechanisms

T Wang, J Wang, X Hu, XJ Huang… - World journal of …, 2020 - ncbi.nlm.nih.gov
Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

Mechanism and regulation of microglia polarization in intracerebral hemorrhage

Y Guo, W Dai, Y Zheng, W Qiao, W Chen, L Peng… - Molecules, 2022 - mdpi.com
Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, but effective treatments
are lacking, and neuroinflammation plays a key role in the pathogenesis. In the innate …

Review on the pharmacological properties of phillyrin

C Zhou, M Lu, J Cheng, ER Rohani, HS Hamezah… - Molecules, 2022 - mdpi.com
Phillyrin is an effective lignan glycoside extracted from a traditional Chinese medicine
Forsythia suspensa (Thunb.) Vahl (Oleaceae). It mainly exists in the roots, stems, leaves and …

[HTML][HTML] Natural products: regulating glucose metabolism and improving insulin resistance

FSA Saadeldeen, Y Niu, H Wang, L Zhou… - Food science and …, 2020 - Elsevier
Compounds with regulating glucose metabolism and improving insulin resistance (IR)
activity are abundant in nature and can be obtained from several sources. They have high …

Phillyrin Prevents Neuroinflammation-Induced Blood–Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization

Q Jiang, D Wei, X He, C Gan, X Long… - Frontiers in …, 2021 - frontiersin.org
Background: Phillyrin (Phi) is the main polyphenolic compound found in Forsythia suspensa.
Recent studies have revealed that Phi has potent antioxidative and anti-inflammatory effects …

[HTML][HTML] Natural and semi-synthetic flavonoid anti-SARS-CoV-2 agents for the treatment of long COVID-19 disease and neurodegenerative disorders of cognitive …

J Melrose, MM Smith - Frontiers in Bioscience-Elite, 2022 - imrpress.com
The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of
widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue …

Analysis of Forsythia suspensa fruit and leaf extracts using UHPLC-Q-Exactive-Orbitrap/MS: In vivo antioxidant activity on D-galactose-induced aging mice

X Wang, Q Jia, X Yao, L Yang, K Pei, L Guo, Y Guo… - Food Chemistry, 2025 - Elsevier
Making health-enhancing tea from Forsythia suspensa leaves has been a tradition of
Chinese folk culture for centuries. However, these leaves were not officially recognized as a …

Analysis of chemical compounds and toxicological evaluation of Forsythia suspensa leaves tea

DH Wang, MY Wang, WH Shen, JF Yuan - Food Science and …, 2021 - Springer
To determine the compositions of Forsythia suspensa leaves tea (FSLT) and its safety, the
chemical compounds were analysed with some methods, and the toxicity was evaluated in …

Phillyrin restores metabolic disorders in mice fed with high-fat diet through inhibition of interleukin-6-mediated basal lipolysis

Z Fang, L Wei, Y Lv, T Wang, HS Hamezah… - Frontiers in …, 2022 - frontiersin.org
The function of white adipose tissue as an energy reservoir is impaired in obesity, leading to
lipid spillover and ectopic lipid deposition. Adipose tissue inflammation can reduce the …