Targeting airway smooth muscle hypertrophy in asthma: An approach whose time has come
A Chetty, HC Nielsen - Journal of asthma and allergy, 2021 - Taylor & Francis
Airway smooth muscle (ASM) cell dysfunction is an important component of several
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …
Update in adult asthma 2020
AJ Halayko, CD Pascoe, JD Gereige… - American Journal of …, 2021 - atsjournals.org
In this 2020 Update of publications in AmericanThoracicSociety (ATS) journals, we review
breakthroughs in understanding of pathophysiology, treatment, and risk factors for asthma …
breakthroughs in understanding of pathophysiology, treatment, and risk factors for asthma …
Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice
NC Stevens, VJ Brown, MC Domanico… - Toxicological …, 2023 - academic.oup.com
Asthma is a common chronic respiratory disease exacerbated by multiple environmental
factors. Acute ozone exposure has previously been implicated in airway inflammation …
factors. Acute ozone exposure has previously been implicated in airway inflammation …
Metabolic adaptation of airway smooth muscle cells to an SPHK2 substrate precedes cytostasis
Thickening of the airway smooth muscle is central to bronchial hyperreactivity. We have
shown that the sphingosine analog (R)-2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol …
shown that the sphingosine analog (R)-2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol …
S1P 在哮喘中的研究现状及应用前景.
袁宸， 赵霞， 吴嘉宝， 严花 - Journal of Practical Medicine …, 2024 - search.ebscohost.com
哮喘是一种慢性气道炎症性疾病, 气道炎症, 气道高反应及气道重塑等是哮喘的主要病理改变.
大量研究表明哮喘患者中存在鞘酯代谢紊乱, 鞘氨醇-1-磷酸(Sphingosine-1-Phosphate, S1P) …
大量研究表明哮喘患者中存在鞘酯代谢紊乱, 鞘氨醇-1-磷酸(Sphingosine-1-Phosphate, S1P) …
CD200Fc limits dendritic cell and B-cell activation during chronic allergen exposures
D Patoine, K Bouchard, P Blais-Lecours… - 2023 - academic.oup.com
Allergic asthma is a chronic inflammatory disease characterized by Th2, conventional
dendritic cell, and B-cell activation. In addition to excessive inflammation, asthma …
dendritic cell, and B-cell activation. In addition to excessive inflammation, asthma …
Give me some room to breathe! Can targeting SPHK2 reduce airway smooth muscle thickening in asthma?
JL Ingram - American journal of respiratory cell and molecular …, 2020 - atsjournals.org
During the pathobiology of asthma, airway smooth muscle cells (ASMCs) play prominent
roles in all aspects of the disease, including airway inflammation, hyperresponsiveness, and …
roles in all aspects of the disease, including airway inflammation, hyperresponsiveness, and …
Mutant mice and animal models of airway allergic disease
J Brassard, D Marsolais, MR Blanchet - Eosinophils: Methods and …, 2021 - Springer
Eosinophilia is a hallmark of allergic airway inflammation, and eosinophils represent an
integral effector leukocyte through their release of various granule-stored cytokines and …
integral effector leukocyte through their release of various granule-stored cytokines and …
Rôle du récepteur 1 de la sphingosine-1-phosphate dans la pneumopathie d'hypersensibilité
CA Huppé - 2020 - corpus.ulaval.ca
Résumé Hypersensitivity pneumonitis (HP) is a pulmonary disease caused by repetitive
exposure to some components of bioaerosols. HP is characterized by neutrophil recruitment …
exposure to some components of bioaerosols. HP is characterized by neutrophil recruitment …