Dissipative DNA nanotechnology

E Del Grosso, E Franco, LJ Prins, F Ricci - Nature Chemistry, 2022 - nature.com
DNA nanotechnology has emerged as a powerful tool to precisely design and control
molecular circuits, machines and nanostructures. A major goal in this field is to build devices …

Reconfigurable A-motif, i-motif and triplex nucleic acids for smart pH-responsive DNA hydrogels

Y Hu, JY Ying - Materials Today, 2023 - Elsevier
Integrating dynamic reconfigurable DNA crosslinking units, smart DNA hydrogels have
demonstrated sol–gel transition, shape memory, self-healing, sensing, cargo encapsulation …

A DNA nanodevice-based vaccine for cancer immunotherapy

S Liu, Q Jiang, X Zhao, R Zhao, Y Wang, Y Wang… - Nature Materials, 2021 - nature.com
A major challenge in cancer vaccine therapy is the efficient delivery of antigens and
adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we …

Functional DNA-based cytoskeletons for synthetic cells

P Zhan, K Jahnke, N Liu, K Göpfrich - Nature chemistry, 2022 - nature.com
The cytoskeleton is an essential component of a cell. It controls the cell shape, establishes
the internal organization, and performs vital biological functions. Building synthetic …

Autonomous dynamic control of DNA nanostructure self-assembly

LN Green, HKK Subramanian, V Mardanlou, J Kim… - Nature …, 2019 - nature.com
Biological cells routinely reconfigure their shape using dynamic signalling and regulatory
networks that direct self-assembly processes in time and space, through molecular …

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

E Del Grosso, P Irmisch, S Gentile… - Angewandte Chemie …, 2022 - Wiley Online Library
Here we show a general approach to achieve dissipative control over toehold‐mediated
strand‐displacement, the most widely employed reaction in the field of DNA …

DNA assembly‐based stimuli‐responsive systems

S Lu, J Shen, C Fan, Q Li, X Yang - Advanced Science, 2021 - Wiley Online Library
Stimuli‐responsive designs with exogenous stimuli enable remote and reversible control of
DNA nanostructures, which break many limitations of static nanostructures and inspired …

Proton gradients from light-harvesting E. coli control DNA assemblies for synthetic cells

K Jahnke, N Ritzmann, J Fichtler, A Nitschke… - Nature …, 2021 - nature.com
Bottom-up and top-down approaches to synthetic biology each employ distinct
methodologies with the common aim to harness living systems. Here, we realize a strategic …

Dynamic self-assembly of compartmentalized DNA nanotubes

S Agarwal, MA Klocke, PE Pungchai… - Nature communications, 2021 - nature.com
Bottom-up synthetic biology aims to engineer artificial cells capable of responsive behaviors
by using a minimal set of molecular components. An important challenge toward this goal is …

Dna origami signaling units transduce chemical and mechanical signals in synthetic cells

K Jahnke, M Illig, M Scheffold, MP Tran… - Advanced Functional …, 2024 - Wiley Online Library
Transmembrane proteins transmit chemical signals as well as mechanical cues. The latter is
often achieved by coupling to the cytoskeleton. The incorporation of fully engineerable …