Cell migration and degradation of the extracellular matrix (ECM) are crucial steps in tumor
progression. Several matrix-degrading proteases, including matrix metalloproteases, are …

Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …

Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial
function. Taking the natural hard tissue structure as a template, constructing an engineered …

Multiple myeloma (MM) expands in the bone marrow and causes devastating bone
destruction by enhancing osteoclastic bone resorption in its vicinity, suggesting a close …

Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and
bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of …

The ability of bone to resist catastrophic failure is critically dependent upon the material
properties of bone matrix, a composite of hydroxyapatite, collagen type I, and …

Mineralized collagen composites are of interest because they have the potential to provide a
bone-like scaffold that stimulates the natural processes of resorption and remodeling …

Osteopontin (OPN), a glycosylated phosphoprotein that binds calcium, is present in bone
extracellular matrix and has been reported to modulate both mineralization and bone …

Herba Epimedii (HEP) known as YinYangHuo in Chinese is the dried leaf of the
Epimediium, and has been historically used in combination with other herbs to treat skeletal …