Leishmaniasis is a neglected disease resulting in a global morbidity of 2,090 thousand
Disability‐Adjusted Life Years and a mortality rate of approximately 60,000 per year. Among …

Zoonotic visceral leishmaniasis, caused by the intracellular protozoan parasite Leishmania
infantum, is a neglected tropical disease that is often fatal when untreated. Dogs are …

Leishmania donovani (LD), the causative agent of visceral leishmaniasis (VL), extracts
membrane cholesterol from macrophages and disrupts lipid rafts, leading to their inability to …

NKT cells play an important role in autoimmune diseases, tumor surveillance, and infectious
diseases, providing in most cases protection against infection. NKT cells are reactive to …

Resistance to murine visceral leishmaniasis (VL) correlates with the development of an IFN‐
γ predominant immune response. Beta1, 4‐galactose terminal glycans are potent inducers …

In vitro and in vivo anti-leishmanial efficacy of copper salisylaldoxime (CuSAL), a transition
metal complex, was evaluated and the underlying mechanism was studied. In vitro studies …

Abstract Treatment against visceral leishmaniasis (VL) presents problems by the toxicity of
drugs, high cost and/or emergence of resistant strains. The diagnosis is hampered by …

Leishmaniasis is a parasite-mediated tropical disease affecting millions of individuals
worldwide. The available antileishmanial chemotherapeutic modalities exhibit adverse …

During Leishmania donovani (LD) infection Interleukin (IL)-10 favors parasite replication and
plays a central role as a target for immune-based therapy. Glycogen synthase kinase 3 …

NKT cells respond to presentation of specific glycolipids with release of both Th1‐and Th2‐
type cytokines. Leishmania donovani (LD)‐infected splenic macrophages (sMϕ (I)) and …