Castleman disease (CD) describes a group of heterogeneous hematologic disorders with
characteristic histopathological features. CD can present with unicentric or multicentric …

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

Summary Background Multicentric Castleman's disease describes a group of poorly
understood lymphoproliferative disorders driven by proinflammatory hypercytokinaemia …

In the complex interplay between malignant cells and their microenvironment, caspase-1
activation complexes (inflammasomes) have contrasting roles. Inflammasomes may operate …

Multicentric Castleman's disease (MCD) describes a heterogeneous group of disorders
involving proliferation of morphologically benign lymphocytes due to excessive …

Castleman disease (CD) describes a heterogeneous group of hematologic disorders that
share characteristic lymph node histopathology. Patients of all ages present with either a …

Castleman disease (CD) comprises 3 poorly understood lymphoproliferative variants
sharing several common histopathological features. Unicentric CD (UCD) is localized to a …

Castleman disease (CD) is a rare lymphoproliferative disorder affecting single (unicentric;
UCD) or multiple (multicentric; MCD) lymph nodes. The incidence of this difficult to diagnose …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the centricity and histopathology profiles of each of the three classes of HIV …