Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly
expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at …

Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of
Aβ plaques that characterize Alzheimer's disease (AD). Aβ is cleared in part by the …

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and
to be most effective during sleep. Ablation of the astrocytic end-feet expressed water …

Astrocytes are the most numerous type of neuroglia in the brain and have a predominant
influence on the cerebrovascular system; they control perivascular homeostasis, the integrity …

Alzheimer's disease is initiated by the toxic aggregation of amyloid-β. Immunotherapeutics
aimed at reducing amyloid beta are in clinical trials but with very limited success to date …

The neurovascular unit (NVU) consists of cells intrinsic to the vessel wall, the endothelial
cells and pericytes, and astrocyte endfeet that surround the vessel but are separated from it …

In the past, water homeostasis of the brain was understood as a certain quantitative
equilibrium of water content between intravascular, interstitial, and intracellular spaces …

The central nervous system is highly dependent on water, and disturbances in water
homeostasis can have a significant impact on its normal functions. The regulation of water …