MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

The origin of RNA interference (RNAi) is usually explained by a defense-based hypothesis,
in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses …

RNA interference (RNAi)-related pathways target viruses and transposable element (TE)
transcripts in plants, fungi, and ecdysozoans (nematodes and arthropods), giving protection …

Eukaryotic genomes contain virus-derived sequences called endogenous virus elements
(EVEs). The majority of EVEs are related to retroviruses, which integrate into the host …

RNAi promises to reshape pest control by being nontoxic, biodegradable, and species
specific. However, due to the plastic nature of RNAi, there is a significant variability in …

The advent of complete genomic sequencing has opened a window into genomic
phenomena obscured by fragmented assemblies. A good example of these is the existence …

All animals have evolved solutions to manage their genomes, enabling the efficient
organization of meters of DNA strands in the nucleus and allowing for nuanced regulation of …

The chromatin environment plays a central role in regulating developmental gene
expression in metazoans. Yet, the ancestral regulatory landscape of metazoan …

As fundamental components of RNA silencing, small RNA (sRNA) molecules ranging from
20 to 32 nucleotides in length have been found as potent regulators of gene expression and …

MicroRNAs (miRNAs) base-pair to messenger RNA targets and guide Argonaute proteins to
mediate their silencing. This target regulation is considered crucial for animal physiology …