New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
[HTML][HTML] Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle
Q Ouyang, Q Chen, S Ke, L Ding, X Yang, P Rong… - Developmental Cell, 2023 - cell.com
Dynamic interaction between lipid droplets (LDs) and mitochondria controls the mobilization
of long-chain fatty acids (LCFAs) from LDs for mitochondrial β-oxidation in skeletal muscle in …
of long-chain fatty acids (LCFAs) from LDs for mitochondrial β-oxidation in skeletal muscle in …
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
D Ahwazi, K Neopane, GR Markby, F Kopietz… - Biochemical …, 2021 - portlandpress.com
SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has
recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) …
recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) …
Fine-tuning AMPK in physiology and disease using point-mutant mouse models
N Ashraf, JL Van Nostrand - Disease Models & Mechanisms, 2024 - journals.biologists.com
ABSTRACT AMP-activated protein kinase (AMPK) is an evolutionarily conserved
serine/threonine kinase that monitors the cellular energy status to adapt it to the fluctuating …
serine/threonine kinase that monitors the cellular energy status to adapt it to the fluctuating …
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis
K Neopane, N Kozlov, F Negoita, L Murray-Segal… - Cell Reports, 2022 - cell.com
AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis
and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of …
and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of …
AMPKγ3 controls muscle glucose uptake in recovery from exercise to recapture energy stores
K Kido, NO Eskesen, NS Henriksen, J Onslev… - Diabetes, 2023 - Am Diabetes Assoc
Exercise increases muscle glucose uptake independently of insulin signaling and
represents a cornerstone for the prevention of metabolic disorders. Pharmacological …
represents a cornerstone for the prevention of metabolic disorders. Pharmacological …
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1
G Ren, YW Ding, LL Wang, JD Jiang - Frontiers in pharmacology, 2023 - frontiersin.org
Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and
metformin on metabolic improvement. The present study investigated the mechanism of BBR …
metformin on metabolic improvement. The present study investigated the mechanism of BBR …
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator
The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy
sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with …
sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with …
Natural (dihydro) phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site
MJ Sanders, Y Ratinaud, K Neopane… - Journal of Biological …, 2022 - ASBMB
AMP-activated protein kinase (AMPK) is a central energy sensor that coordinates the
response to energy challenges to maintain cellular ATP levels. AMPK is a potential …
response to energy challenges to maintain cellular ATP levels. AMPK is a potential …
Acute, next‐generation AMPK activation initiates a disease‐resistant gene expression program in dystrophic skeletal muscle
Duchenne muscular dystrophy (DMD) is a life‐limiting neuromuscular disorder
characterized by muscle weakness and wasting. Previous proof‐of‐concept studies …
characterized by muscle weakness and wasting. Previous proof‐of‐concept studies …