Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
The incidence of chronic kidney diseases is increasing worldwide, and these conditions are
emerging as a major public health problem. While genetic factors contribute to susceptibility …
emerging as a major public health problem. While genetic factors contribute to susceptibility …
Cell senescence in the aging kidney
Pedigree genetics and environment modulate the biological process of aging. The
permanent and irreversible growth arrest of cell senescence is a central paradigm of aging …
permanent and irreversible growth arrest of cell senescence is a central paradigm of aging …
Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression
W Cai, JC He, L Zhu, X Chen, S Wallenstein… - The American journal of …, 2007 - Elsevier
Aging is accompanied by increased oxidative stress (OS) and accumulation of advanced
glycation end products (AGEs). AGE formation in food is temperature-regulated, and …
glycation end products (AGEs). AGE formation in food is temperature-regulated, and …
[HTML][HTML] Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation
J Wu, R Zhang, M Torreggiani, A Ting, H Xiong… - The American journal of …, 2010 - Elsevier
Kidney aging is a slowly progressive process that is postulated to be accelerated by
intervening diseases, such as diabetes, due in part to the addition of excessive stress and …
intervening diseases, such as diabetes, due in part to the addition of excessive stress and …
[HTML][HTML] ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease
A Remuzzi, E Gagliardini, F Sangalli, M Bonomelli… - Kidney international, 2006 - Elsevier
Today angiotensin II inhibition is primarily used to slow the rate of progression of kidney
diseases. There is evidence that these therapies can induce a partial regression of …
diseases. There is evidence that these therapies can induce a partial regression of …
The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease
Aging induces morphological changes of the kidney and reduces renal function. We
analyzed the low molecular weight urinary proteome of 324 healthy individuals from 2–73 …
analyzed the low molecular weight urinary proteome of 324 healthy individuals from 2–73 …
Therapeutic benefits of young, but not old, adipose-derived mesenchymal stem cells in a chronic mouse model of bleomycin-induced pulmonary fibrosis
J Tashiro, SJ Elliot, DJ Gerth, X Xia… - Translational …, 2015 - Elsevier
The observation that pulmonary inflammatory lesions and bleomycin (BLM)-induced
pulmonary fibrosis spontaneously resolve in young mice, whereas remaining irreversible in …
pulmonary fibrosis spontaneously resolve in young mice, whereas remaining irreversible in …
[HTML][HTML] Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15
X Gao, L Huang, F Grosjean, V Esposito, J Wu, L Fu… - Kidney international, 2011 - Elsevier
Dietary protein restriction is an important treatment for chronic kidney disease. Herein, we
tested the effect of low-protein or low-protein plus ketoacids (KA) diet in a remnant kidney …
tested the effect of low-protein or low-protein plus ketoacids (KA) diet in a remnant kidney …
Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in …
H Vlassara, J Uribarri, L Ferrucci, W Cai… - Seminars in …, 2009 - Elsevier
Aging is characterized by increasing inflammation and oxidant stress (OS). Reduced renal
function was present in more than 20% of normal-aged individuals sampled in the National …
function was present in more than 20% of normal-aged individuals sampled in the National …
Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the …
M Son, WJ Chung, S Oh, H Ahn, CH Choi, S Hong… - Immunity & …, 2017 - Springer
Background Much evidence indicates receptor for advanced glycation end products (RAGE)
related inflammation play essential roles during aging. However, the majority of studies have …
related inflammation play essential roles during aging. However, the majority of studies have …