The halogen-atom transfer (XAT) is one of the most important and applied processes for the
generation of carbon radicals in synthetic chemistry. In this review, we summarize and …

Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

The polarity of a radical intermediate profoundly impacts its reactivity and selectivity. To
quantify this influence and predict its effects, the electrophilicity/nucleophilicity of> 500 …

Herein, we report a new class of electrophotocatalysts, polycyclic aromatic hydrocarbons,
that promote the reduction of unactivated carbonyl compounds to generate versatile ketyl …

Carbenes are highly enabling reactive intermediates that facilitate a diverse range of
otherwise inaccessible chemistry, including small-ring formation and insertion into strong σ …

Carbonyls and alkenes are versatile functional groups, whose reactivities are cornerstones
of organic synthesis. The selective combination of two carbonyls to form an alkene—a …

α-Tertiary amines are a common motif in pharmaceutically important molecules but are
challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin …

The formation of carbon–carbon bonds lies at the heart of synthetic organic chemistry and is
widely applied to construct complex drugs, polymers, and materials. Despite its importance …

Chiral β-amino alcohols are crucial structural motifs found in pharmaceuticals, natural
products, and chiral ligands in asymmetric catalysis. Despite previous advances, the …

Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple
stereocenters from readily accessible pyrrolidines using iodonitrene chemistry. Mediated by …