How oxygenation shapes immune responses: Emerging roles for physioxia and pathological hypoxia

AS Mirchandani, MA Sanchez-Garcia… - Nature Reviews …, 2024 - nature.com
Most eukaryotes require oxygen for their survival and, with increasing multicellular
complexity, oxygen availability and delivery rates vary across the tissues of complex …

Tailor-made polysaccharides for biomedical applications

M Khodadadi Yazdi, F Seidi, A Hejna… - ACS Applied Bio …, 2024 - ACS Publications
Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the
biomedical field, either in their pure form or in blends/nanocomposites with other materials …

Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing

N Rostami, MM Gomari, E Choupani, S Abkhiz… - Small …, 2024 - Wiley Online Library
The genetic material within cells plays a pivotal role in shaping the structure and function of
living organisms. Manipulating an organism's genome to correct inherited abnormalities or …

Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions

ZJ Rogers, T Colombani, S Khan, K Bhatt… - Advanced …, 2024 - Wiley Online Library
Abstract In oxygen (O2)‐controlled cell culture, an indispensable tool in biological research,
it is presumed that the incubator setpoint equals the O2 tension experienced by cells (ie …

[HTML][HTML] Progress in ATRP-derived materials for biomedical applications

MK Yazdi, P Zarrintaj, MR Saeb, M Mozafari… - Progress in Materials …, 2024 - Elsevier
The continuing wave of technological breakthroughs and advances is critical for engineering
well-defined materials, particularly biomaterials, with tailored microstructure and properties …

“Targeted plus controlled”–Composite nano delivery system opens the tumor vascular and microenvironment normalization window for anti-tumor therapy

R Shen, Q Jiang, P Li, D Wang, C Yu, T Meng… - International Journal of …, 2023 - Elsevier
The bottleneck of traditional anti-tumor therapy is mainly limited by the abnormal
microenvironment of tumors. Leaky vessels are difficult for drugs or immune cells to …

[HTML][HTML] Synthesis and characterization of photo-cross-linkable quince seed-based hydrogels for soft tissue engineering applications

A Jafari, K Bhatt, SV Niknezhad, A Ajji, M Griffith… - Carbohydrate …, 2025 - Elsevier
The convenience, versatility, and biocompatibility of photocrosslinkable hydrogel precursors
make them promising candidates for developing tissue engineering scaffolds. However, the …

Photothermal Particle-Loaded Panax Notoginseng Polysaccharide Cryogels As Personalized Tumor Vaccines

H Ni, S Yu, S Qian, J Lu, J Feng, J Zhang - Biomacromolecules, 2024 - ACS Publications
Combination immunotherapy is being increasingly explored for cancer treatment, leading to
various vector materials for the codelivery of immune agents and drugs. However, current …

Biomaterial-assisted local oxygenation safeguards the prostimulatory phenotype and functions of human dendritic cells in hypoxia

K Bhatt, A Nukovic, T Colombani… - Frontiers in …, 2023 - frontiersin.org
Dendritic cells (DCs), professional antigen-presenting cells, function as sentinels of the
immune system. DCs initiate and fine-tune adaptive immune responses by presenting …

Hypoxia‐activated ADCC‐enhanced humanized anti‐CD147 antibody for liver cancer imaging and targeted therapy with improved selectivity

FZ Qi, HS Su, B Wang, LM Qian, Y Wang… - MedComm, 2024 - Wiley Online Library
Therapeutic antibodies (Abs) improve the clinical outcome of cancer patients. However, on‐
target off‐tumor toxicity limits Ab‐based therapeutics. Cluster of differentiation 147 (CD147) …