We developed a generalized technique to characterize polymer–nanopore interactions via
single channel ionic current measurements. Physical interactions between analytes, such as …

Spike-sorting techniques attempt to classify a series of noisy electrical waveforms according
to the identity of the neurons that generated them. Existing techniques perform this …

Gonadotropin-releasing hormone (GnRH) neurons produce the central output controlling
fertility and are regulated by steroid feedback. A switch from estradiol negative to positive …

Ion channels are characterized by inherently stochastic behavior which can be represented
by continuous-time Markov models (CTMM). Although methods for collecting data from …

Nanopore-based sensing is an emerging analytical technique with a number of important
applications, including single-molecule detection and DNA sequencing. In this paper, we …

In single-molecule experiments on the interaction between myosin and actin, mechanical
events are embedded in Brownian noise. Methods of detecting events have progressed from …

We consider a multidimensional, continuous-time model where the observation process is a
diffusion with drift and volatility coefficients being modeled as continuous-time, finite-state …

Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca2+
dynamics in heart. The processes of activation, inactivation, and regulation of these …

Continuous-time Markov chains are used to model systems in which transitions between
states as well as the time the system spends in each state are random. Many computational …

In many cell types, the inositol trisphosphate receptor (IPR) is one of the important
components that control intracellular calcium dynamics, and an understanding of this …