Inflammatory activation is increasingly recognized as a nonconventional risk factor for
arrhythmias, and experimental studies provided robust evidence that this association is …

Almost 200 years ago, the first evidence described by Robert Bright (1836) showed the
strong interaction between the kidneys and heart and, since then, the scientific community …

Background Renal ischemia and reperfusion injury (IRI) is the main cause of acute kidney
injury (AKI). AKI induces the development of cardiac hypertrophy (CH) during cardiorenal …

Calcium/calmodulin-dependent protein kinases (CaMKs) are key regulators of calcium
signaling in health and disease. CaMKII is the most abundant isoform in the heart; although …

Background: Cardiovascular comorbidities such as hypertension and inflammatory
response dysregulation are associated with worse COVID-19 prognoses. Different cytokines …

In the heart, cardiac macrophages have widespread biological functions, including roles in
antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse …

Mortality in acute kidney injury (AKI) remains very high, yet the cause of death is often failure
of extrarenal organs. We and others have demonstrated remote organ dysfunction after …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are global health burdens with
rising prevalence. Their bidirectional relationship with cardiovascular dysfunction …

Renal injury caused by renal ischemia and reperfusion strongly influences heart
morphology, electrophysiology, and redox unbalance. The so-called cardiorenal syndrome …

Background: Acute renal failure (ARF) following renal ischemia-reperfusion (I/R) injury is
considered a relevant risk factor for cardiac damage, but the underlying mechanisms …