Neurocognitive deficit in schizophrenia: a quantitative review of the evidence.

RW Heinrichs, KK Zakzanis - Neuropsychology, 1998 - psycnet.apa.org
The neurocognitive literature on test performance in schizophrenia is reviewed
quantitatively. The authors report 22 mean effect sizes from 204 studies to index …

The neuropathology of schizophrenia: a critical review of the data and their interpretation

PJ Harrison - Brain, 1999 - academic.oup.com
Despite a hundred years' research, the neuropathology of schizophrenia remains obscure.
However, neither can the null hypothesis be sustained—that it is afunctional'psychosis, a …

Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis?

E Bora, RM Murray - Schizophrenia bulletin, 2014 - academic.oup.com
Cognitive dysfunction is a well-established feature of schizophrenia, and there is evidence
suggesting that cognitive deficits are secondary to abnormal neurodevelopment leading to …

Cognitive control deficits in schizophrenia: mechanisms and meaning

TA Lesh, TA Niendam, MJ Minzenberg… - …, 2011 - nature.com
Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

The myth of schizophrenia as a progressive brain disease

RB Zipursky, TJ Reilly, RM Murray - Schizophrenia bulletin, 2013 - academic.oup.com
Schizophrenia has historically been considered to be a deteriorating disease, a view
reinforced by recent MRI findings of progressive brain tissue loss over the early years of …

The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model

J Read, BD Perry, A Moskowitz, J Connolly - Psychiatry, 2001 - Taylor & Francis
The current diathesis-stress model of schizophrenia proposes that a genetic deficit creates a
predisposing vulnerability in the form of oversenstivity to stress. This model positions all …

Schizophrenia as a disorder of developmentally reduced synaptic connectivity

TH McGlashan, RE Hoffman - Archives of general psychiatry, 2000 - jamanetwork.com
Recent postmortem and neuroimaging studies of schizophrenia delineate changes in brain
structure and volume that appear to arise from a reduction of neuritic processes (such as …

Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect

TW Weickert, TE Goldberg, JM Gold… - Archives of general …, 2000 - jamanetwork.com
Background Although intellectual and neurocognitive deficits accompany schizophrenia,
there are inconsistencies in the literature concerning issues of intellectual decline …

Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study

MH Meier, A Caspi, A Reichenberg… - American Journal of …, 2014 - Am Psychiatric Assoc
Objective Despite the widespread belief that neuropsychological decline is a cardinal
feature of the progression from the premorbid stage to the chronic form of schizophrenia, few …

Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents

M Davidson, A Reichenberg… - American Journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: Subtle behavioral and intellectual abnormalities are often present in apparently
healthy adolescents who later develop schizophrenia. The authors investigated whether …