CRISPR-Cas13 in malaria parasite: Diagnosis and prospective gene function identification

E Quansah, Y Chen, S Yang, J Wang, D Sun… - Frontiers in …, 2023 - frontiersin.org
Malaria caused by Plasmodium is still a serious public health problem. Genomic editing is
essential to understand parasite biology, elucidate mechanical pathways, uncover gene …

Molecular markers for malaria genetic epidemiology: progress and pitfalls

S Ruybal-Pesántez, K McCann, J Vibin, S Siegel… - Trends in …, 2023 - cell.com
Over recent years, progress in molecular markers for genotyping malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …

Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high …

AT Kayode, FV Ajogbasile, K Akano, JN Uwanibe… - Scientific reports, 2021 - nature.com
Abstract In 2005, the Nigerian Federal Ministry of Health revised the treatment policy for
uncomplicated malaria with the introduction of artemisinin-based combination therapies …

Bias-corrected maximum-likelihood estimation of multiplicity of infection and lineage frequencies

M Hashemi, KA Schneider - PloS one, 2021 - journals.plos.org
Background The UN's Sustainable Development Goals are devoted to eradicate a range of
infectious diseases to achieve global well-being. These efforts require monitoring disease …

Genetic diversity and population structure of Plasmodium falciparum in Nigeria: insights from microsatellite loci analysis

FV Ajogbasile, AT Kayode, PE Oluniyi, KO Akano… - Malaria Journal, 2021 - Springer
Background Malaria remains a public health burden especially in Nigeria. To develop new
malaria control and elimination strategies or refine existing ones, understanding parasite …

Baseline prevalence of molecular marker of sulfadoxine/pyrimethamine resistance in Ebonyi and Osun states, Nigeria: amplicon deep sequencing of dhps-540

AY Olukosi, O Ajibaye, O Omoniwa… - Journal of …, 2023 - academic.oup.com
Background Chemoprevention plays an important role in malaria control strategy. Perennial
malaria chemoprevention (PMC) using sulfadoxine/pyrimethamine (SP) is a WHO-approved …

Post-genomic approaches to understanding malaria parasite biology: linking genes to biological functions

AE Sexton, C Doerig, DJ Creek… - ACS Infectious …, 2019 - ACS Publications
Plasmodium species are evolutionarily distant from model eukaryotes, and as a
consequence they exhibit many non-canonical cellular processes. In the post-genomic era …

Plasmodium vivax populations in the western Greater Mekong Subregion evaluated using a genetic barcode

Y Hu, Y Li, AM Brashear, W Zeng, Z Wu… - PLOS Neglected …, 2024 - journals.plos.org
An improved understanding of the Plasmodium vivax populations in the Great Mekong
Subregion (GMS) is needed to monitor the progress of malaria elimination. This study aimed …

A genotyping assay to determine geographic origin and transmission potential of Plasmodium falciparum malaria cases

A Molina-Cruz, N Raytselis, R Withers… - Communications …, 2021 - nature.com
As countries work towards malaria elimination, it is important to monitor imported cases to
prevent reestablishment of local transmission. The Plasmodium falciparum Pfs47 gene has …

[PDF][PDF] The H3Africa Consortium: publication outputs of a pan-African genomics collaboration (2013 to 2020)

A Choudhury, D Sengupta, S Aron… - Africa, the Cradle of …, 2021 - library.oapen.org
Developing a complex collaborative program across multiple African countries,
characterized by a diversity of government models, laws, cultures and norms, resources and …