Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded
protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and …

Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis,
metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules …

FLT3 kinase is a potential drug target in acute myeloid leukemia (AML). Patients with FLT3
mutations typically have higher relapse rates and worse outcomes than patients without …

Pyridazine, as a privileged scaffold, has been extensively utilized in drug development due
to its multiple biological activities. Especially around its distinctive anticancer property, a …

The unfolded protein response (UPR) is a cellular mechanism that protects cells during
stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic …

The endoplasmic reticulum (ER) is responsible for structural transformation or folding of de
novo proteins for transport to the Golgi. When the folding capacity of the ER is exceeded or …

Inositol-requiring enzyme 1 α (IRE1α) is a type I transmembrane protein that resides in the
endoplasmic reticulum (ER). IRE1α, which is the primary sensor of ER stress, has been …

Abstract HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding) RNases are an
emerging class of functionally diverse RNA processing and degradation enzymes. Members …

Full-length Bruton's tyrosine kinase (BTK) has been refractory to structural analysis. The
nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase …