Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-
inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates …

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

The intestine constantly encounters and adapts to the external environment shaped by
diverse dietary nutrients. However, whether and how gut adaptability to dietary challenges is …

Tumour growth and dissemination is largely dependent on nutrient availability. It has
recently emerged that the tumour microenvironment is rich in a diverse array of lipids that …

Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …

Trillions of microbes are indigenous to the human gastrointestinal tract, together forming an
ecological community known as the gut microbiota. The gut microbiota is involved in dietary …

Saturated fatty acids possess few health benefits compared to unsaturated fatty acids.
However, increasing experimental evidence demonstrates the nutritionally beneficial role of …

A high intratumoral nerve density is correlated with poor survival, high metastasis, and high
recurrence across multiple solid tumor types. Recent research has revealed that cancer cells …

Ferroptosis, a type of programmed cell death caused by lipid peroxidation has recently been
observed in colitis. Whether a high-fat diet (HFD) affects ferroptosis and whether it …