Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are
recruited into the tumor site to fight against tumors. However, their small number and …

The outcome of tumors results from genetic and epigenetic modifications of the transformed
cells and also from the interactions of the malignant cells with their tumor microenvironment …

A complex network of chemokines can influence cancer progression with the recruitment
and activation of hematopoietic cells, including macrophages to the supporting tumor stroma …

Inflammation influences cancer development and progression, and a low lymphocyte to
monocyte ratio (LMR) has been reported to be a poor prognostic indicator in several …

Disease outcomes of HER2+ breast cancers have dramatically improved after targeted
therapies, such as trastuzumab became available. The main mechanism of action of …

Background An increasing number of studies have investigated the prognostic value of the
lymphocyte-to-monocyte ratio (LMR) in various types of cancer. The present meta-analysis …

Background Cancer cachexia is a complex wasting syndrome affecting patients with
advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein …

Colorectal cancer (CRC) is the second cause of cancer death worldwide. The metastatic
disease is mainly treated with aggressive therapies consisting on combinations of cytotoxic …