Targeting the NF-κB pathway for therapy of ischemic stroke
JA Howell, GL Bidwell III - Therapeutic delivery, 2020 - Taylor & Francis
Ischemic strokes occur when a major cerebral artery or its branches are occluded, resulting
in activation of inflammatory processes that cause secondary tissue injury, breakdown of the …
in activation of inflammatory processes that cause secondary tissue injury, breakdown of the …
Genetic diagnosis in hereditary hemochromatosis: discovering and understanding the biological relevance of variants
Background Hereditary hemochromatosis (HH) is a genetic disease, leading to iron
accumulation and possible organ damage. Patients are usually homozygous for p …
accumulation and possible organ damage. Patients are usually homozygous for p …
Acetylated oligopeptide and n-acetyl cysteine protected against oxidative stress, inflammation, testicular-blood barrier damage, and testicular cell death in iron …
Multiple organs, including the testes, are damaged by iron overload. It has been shown that
N-acetyl cysteine (NAC) influences oxidative stress in iron overload. The present study …
N-acetyl cysteine (NAC) influences oxidative stress in iron overload. The present study …
Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver
Inflammation is a constant in Non-Alcoholic Fatty Liver Disease (NAFLD), although their
relationship is unclear. In a transgenic zebrafish system with chronic systemic …
relationship is unclear. In a transgenic zebrafish system with chronic systemic …
[HTML][HTML] Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia
M Argenziano, C Tortora, A Di Paola, E Pota… - Oncotarget, 2021 - ncbi.nlm.nih.gov
Pediatric acute myeloid leukemia (AML) represents 20% of total childhood leukemia
diagnoses and is characterized by poor prognosis with a long-term survival rate around the …
diagnoses and is characterized by poor prognosis with a long-term survival rate around the …
Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorate disease-like phenotypes in embryo
Z Asad, C Sachidanandan - European journal of medical genetics, 2020 - Elsevier
CHARGE syndrome is an autosomal dominant congenital disorder caused primarily by
mutations in the CHD7 gene. Using a small molecule screen in a zebrafish model of …
mutations in the CHD7 gene. Using a small molecule screen in a zebrafish model of …
BML-257, a small molecule that protects against drug-induced liver injury in zebrafish
The use of many essential drugs is restricted due to their deleterious effects on the liver.
Molecules that can prevent or protect the liver from drug-induced liver injury (DILI) would be …
Molecules that can prevent or protect the liver from drug-induced liver injury (DILI) would be …
Chronic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver
MK Singh, R Jayarajan, S Varshney, S Upadrasta… - bioRxiv, 2020 - biorxiv.org
Abstract BACKGROUND AND AIMS Inflammation is a constant in Non-Alcoholic Fatty Liver
Disease (NAFLD) and is usually considered a consequence. We propose that inflammation …
Disease (NAFLD) and is usually considered a consequence. We propose that inflammation …