The voltage-gated proton channel Hv1 is a newly discovered ion channel that is highly
conserved among species. It is known that Hv1 is not only expressed in peripheral immune …

With a single gene encoding HV1 channel, proton channel diversity is particularly low in
mammals compared to other members of the superfamily of voltage-gated ion channels …

Context Ellagic acid (EA) is used in traditional medicine to treated hyperlipidaemia.
Objective This study examined if AMPK mediates the anti-steatotic effect of ellagic acid (EA) …

Perfluorohexane sulfonate (PFHxS) is one of the short-chain perfluoroalkyl substances
(PFASs), and frequently detected in the environment, humans, and wildlife, but a detailed …

ATP is an important molecule implicated in diverse biochemical processes, including the
modulation of ion channel and transporter activity. The voltage‐gated proton channel (Hv1) …

Gating of the voltage-gated proton channel HV1 is strongly controlled by pH. There is
evidence that this involves the sidechains of titratable amino acids that change their …

Hv1 is the only voltage-gated proton-selective channel in mammalian cells. It contains a
conserved voltage-sensor domain, shared by a large class of voltage-gated ion channels …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder (NDD). In the
central nervous system (CNS), immune cells like microglia could reprogram intracellular …

The human voltage-gated proton channel (hHv1) is a highly selective ion channel codified
by the HVCN1 gene. It plays a fundamental role in several physiological processes such as …

Multimerization of ion channels is essential for establishing the ion-selective pathway and
tuning the gating regulated by membrane potential, second messengers, and temperature …