DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

DNA methylation and histone modification are epigenetic mechanisms that result in altered
gene expression and cellular phenotype. The exact role of methylation in myelodysplastic …

Cancer cells exhibit multiple epigenetic changes with prominent local DNA
hypermethylation and widespread hypomethylation affecting large chromosomal domains …

Abstract Background Differences in 5-hydroxymethylcytosine, 5hmC, distributions may
complicate previous observations of abnormal cytosine methylation statuses that are used …

Ductal carcinoma in situ (DCIS) is a non-invasive type of breast cancer with highly variable
potential of becoming invasive and affecting mortality. Currently, many patients with DCIS …

CTCF plays a vital role in chromatin structure and function. CTCF is ubiquitously expressed
and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal …

Diagnostic markers for both colorectal cancer (CRC) and its precursor lesions are lacking.
Although aberrant methylation of the secretin receptor (SCTR) gene was observed in CRC …

Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to
characterize the molecular mechanisms underlying both processes. DNA methylation is a …

Lung cancer is the leading cause of cancer‑associated mortality due to high incidence and
poor survival rates, irrespective of global variations in its biology and treatment. Changes in …

Recent genome-wide epigenomic and transcription profiling studies have demonstrated that
epigenetic silencing can encompass multiple neighboring genes, termed as long-range …