Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA
superhelicity and unlink double-stranded DNA segments during processes such as …

Because the genome stores all genetic information required for growth and development, it
is of pivotal importance to maintain DNA integrity, especially during cell division, when the …

Somatic mutations in the KEAP1 ubiquitin ligase or its substrate NRF2 (NFE2L2) commonly
occur in human cancer, resulting in constitutive NRF2-mediated transcription of …

Being sessile organisms, plants are ubiquitously exposed to stresses that can affect the DNA
replication process or cause DNA damage. To cope with these problems, plants utilize DNA …

The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within
an intact nuclear envelope, and differs significantly from its human host. Mitosis is …

Tandem affinity purification coupled to mass spectrometry (TAP-MS) is one of the most
advanced methods to characterize protein complexes in plants, giving a comprehensive …

DNA damage threatens the integrity of the genome and has potentially lethal consequences
for the organism. Plant DNA is under continuous assault from endogenous and …

The evolutionary history of horseshoe crabs, spanning approximately 500 million years, is
characterized by remarkable morphological stasis and a low species diversity with only four …

Gene expression is reconfigured rapidly during the cell cycle to execute the cellular
functions specific to each phase. Studies conducted with synchronized plant cell suspension …

Timely progression of the mitotic cell cycle is central for growth and development of plant
organs. Many cell types in plants also enter an alternative cell cycle called the …