Synaptic memory and CaMKII

RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations

R Borghi, M Trivisano, N Specchio, M Tartaglia… - Neuroscience & …, 2023 - Elsevier
Abstract 'Dominant mutations in CAMK2B, encoding a subunit of the calcium/calmodulin-
dependent protein kinase II (CAMK2), a serine/threonine kinase playing a key role in …

Photoactivatable CaMKII induces synaptic plasticity in single synapses

ACE Shibata, HH Ueda, K Eto, M Onda, A Sato… - Nature …, 2021 - nature.com
Optogenetic approaches for studying neuronal functions have proven their utility in the
neurosciences. However, optogenetic tools capable of inducing synaptic plasticity at the …

Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep

D Tone, KL Ode, Q Zhang, H Fujishima… - PLoS …, 2022 - journals.plos.org
The reduced sleep duration previously observed in Camk2b knockout mice revealed a role
for Ca2+/calmodulin-dependent protein kinase II (CaMKII) β as a sleep-promoting kinase …

Intrinsically disordered linkers control tethered kinases via effective concentration

M Dyla, M Kjaergaard - Proceedings of the National …, 2020 - National Acad Sciences
Kinase specificity is crucial to the fidelity of signaling pathways, yet many pathways use the
same kinases to achieve widely different effects. Specificity arises in part from the enzymatic …

Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy

S Tsujioka, A Sumino, Y Nagasawa, T Sumikama… - Science …, 2023 - science.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in synaptic
plasticity. It is a dodecameric serine/threonine kinase that has been highly conserved across …

Structural basis for the concerted antiphage activity in the SIR2–HerA system

F Liao, G Yu, C Zhang, Z Liu, X Li, Q He… - Nucleic Acids …, 2024 - academic.oup.com
Recently, a novel two-gene bacterial defense system against phages, encoding a SIR2
NADase and a HerA ATPase/helicase, has been identified. However, the molecular …

Proteomics on the role of muscone in the “consciousness-restoring resuscitation” effect of musk on ischemic stroke

B Han, Y Zhao, J Yao, N Li, T Fang, Y Wang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Musk is a representative drug of aroma-relieving
traditional Chinese medicine, and it is a commonly used traditional Chinese medicine for the …

CaMKIIδ splice variants in the healthy and diseased heart

J Duran, L Nickel, M Estrada, J Backs… - Frontiers in cell and …, 2021 - frontiersin.org
RNA splicing has been recognized in recent years as a pivotal player in heart development
and disease. The Ca2+/calmodulin dependent protein kinase II delta (CaMKIIδ) is a …

Hub stability in the calcium calmodulin-dependent protein kinase II

CT Chien, H Puhl, SS Vogel, JE Molloy, W Chiu… - Communications …, 2024 - nature.com
The calcium calmodulin protein kinase II (CaMKII) is a multi-subunit ring assembly with a
central hub formed by the association domains. There is evidence for hub polymorphism …