Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients, yet harbours
mutation-derived T cell neoantigens that are suitable for vaccines,. Here in a phase I trial of …

Background Standard first-line chemotherapy for endometrial cancer is paclitaxel plus
carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear …

Background Co-inhibition of poly (ADP-ribose) polymerase (PARP) and androgen receptor
activity might result in antitumour efficacy irrespective of alterations in DNA damage repair …

Cancers originating in the esophagus or esophagogastric junction constitute a major global
health problem. Esophageal cancers are histologically classified as squamous cell …

Lung cancer is the leading cause of mortality and person-years of life lost from cancer
among US men and women. Early detection has been shown to be associated with reduced …

Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

In 2023, the NCCN Guidelines for Hepatobiliary Cancers were divided into 2 separate
guidelines: Hepatocellular Carcinoma and Biliary Tract Cancers. The NCCN Guidelines for …

Purpose: The summary presented herein covers recommendations on the early detection of
prostate cancer and provides a framework to facilitate clinical decision-making in the …