B cells drive neuropathic pain–related behaviors in mice through IgG–Fc gamma receptor signaling

MJ Lacagnina, KF Willcox, N Boukelmoune… - Science translational …, 2024 - science.org
Neuroimmune interactions are essential for the development of neuropathic pain, yet the
contributions of distinct immune cell populations have not been fully unraveled. Here, we …

Combining RNAscope and immunohistochemistry to visualize inflammatory gene products in neurons and microglia

JB Ball, CJ McNulty, SM Green-Fulgham… - Frontiers in Molecular …, 2023 - frontiersin.org
A challenge for central nervous system (CNS) tissue analysis in neuroscience research has
been the difficulty to codetect and colocalize gene and protein expression in the same …

The impact of sex and physical activity on the local immune response to muscle pain

JB Lesnak, K Hayashi, AN Plumb, AJ Janowski… - Brain, behavior, and …, 2023 - Elsevier
Induction of muscle pain triggers a local immune response to produce pain and this
mechanism may be sex and activity level dependent. The purpose of this study was to …

Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain

B Chen, J Guo, C Gong, C Zhu, Y Wu, S Wang… - Scientific Reports, 2025 - nature.com
Neuropathic pain (NP) is a complex and prevalent chronic pain condition that affects millions
of individuals worldwide. Previous studies have shown that prior exercise protects against …

Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury

SM Green-Fulgham, MJ Lacagnina, KF Willcox… - Brain, behavior, and …, 2024 - Elsevier
Regular aerobic activity is associated with a reduced risk of chronic pain in humans and
rodents. Our previous studies in rodents have shown that prior voluntary wheel running can …