The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

The microcirculation is responsible for orchestrating adjustments in vascular tone to match
local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the …

Hypertension (HTN) has recently been determined to be the number one overall risk factor
of disease. With direct and indirect costs amounting to $46.4 billion in 2011 and projections …

Rationale: Telomerase is a nuclear regulator of telomere elongation with recent reports
suggesting a role in regulation of mitochondrial reactive oxygen species. Flow-mediated …

Physical inactivity is a major risk factor for the development of obesity and other
cardiovascular (CV) disease (CVD). Vascular endothelial dysfunction is a key event in the …

In microvessels of patients with coronary artery disease (CAD), flow-mediated dilation (FMD)
is largely dependent upon the endothelium-derived hyperpolarizing factor H 2 O 2. The goal …

Endothelial nitric oxide (NO) is the primary mediator of flow-mediated dilation (FMD) in
human adipose microvessels. Impaired NO-mediated vasodilation occurs after acute and …

Brachial artery flow–mediated vasodilation in exercise-trained (ET) individuals is maintained
after a single bout of heavy resistance exercise compared with sedentary individuals. The …

Objective: Acute strenuous physical exertion impairs arterial function in sedentary adults. We
investigated the effects of 8 weeks of regular aerobic exercise training on acute physical …

Summary The Renin-Angiotensin system plays an important role in the regulation of
systemic blood pressure as well as in fluid and electrolyte balance. It is divided into two …