Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a
wide variety of human tumors. For many years, apoptosis has been considered a non …

CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often
overexpressed on tumor cells and involved in many different processes such as cell …

CAR-T-cell therapy against MM currently shows promising results, but usually with serious
toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma …

Natural Killer (NK) cells act as important regulators in the development and progression of
hematological malignancies and their suppressor activity against Multiple Myeloma (MM) …

Exosomal long noncoding RNAs (lncRNA) derived from cancer cells are implicated in
various processes, including cancer cell proliferation, metastasis, and immunomodulation …

SUMOylation is a reversible modification that involves the covalent attachment of small
ubiquitin-like modifier (SUMO) to target proteins, leading to changes in their localization …

Natural killer (NK) cells are innate immune effectors with potent antitumor activity. However,
tumor cells can create an immunosuppressive microenvironment to escape immune …

Tumor tissue includes cancer cells and normal stromal cells such as vascular endothelial
cells, connective tissue cells (cancer associated fibroblast, mesenchymal stem cell), and …

Multiple Myeloma (MM) is an incurable hematologic malignancy of terminally differentiated
plasma cells (PCs), where immune interactions play a key role in the control of cancer cell …

Simple Summary The growing interest in immunotherapy for the treatment of multiple
myeloma demands a deep knowledge of the complex interactions between malignant and …