Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

T cells can contribute to clearance of respiratory viruses that cause acute-resolving
infections such as SARS-CoV-2, helping to provide long-lived protection against disease …

Tissue-resident memory T (TRM) cells remain poised in the tissue and mediate robust
protection from secondary infection. TRM cells within the intestine and other tissues are …

Most vaccines require multiple doses to induce long-lasting protective immunity in a high
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …

Resident T lymphocytes (TRM) protect tissues during pathogen reexposure. Although TRM
phenotype and restricted migratory pattern are established, we have a limited understanding …

Background Type 1 (T1) inflammation (marked by IFN-γ expression) is now consistently
identified in subsets of asthma cohorts, but how it contributes to disease remains unclear …

Tissue-resident memory T (T RM) cells provide immune defense against local infection and
can inhibit cancer progression. However, it is unclear to what extent chronic inflammation …

Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the
parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells …

Mucosal infections pose a significant global health burden. Antigen-specific tissue-resident
T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic …