The expression of correctly folded and functional heterologous proteins is important in many
biotechnological production processes, whether it is enzymes, biopharmaceuticals or …

The advent of biopharmaceuticals in modern medicine brought enormous benefits to the
treatment of numerous human diseases and improved the well-being of many people …

Purification of recombinant proteins is often achieved using a purification tag which can be
located either at the N-or C-terminus of a passenger protein of interest. Many purification …

Human epidermal growth factor receptor 2 (HER-2) is overexpressed in many malignant
tumors. The anti-HER2 antibody trastuzumab has been approved for treating HER2-positive …

Human fibroblast growth factor 21 (hFGF21) has been characterized as an important
regulator of glucose and lipid metabolism homeostasis. Here, to produce hFGF21 efficiently …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a member of the colony-
stimulating factor (CSF) family, which functions to enhance the proliferation and …

Abstract Fibroblast growth factor-21 (FGF-21) is a potential cytokine for type II diabetes
mellitus. This study aimed to optimize recombinant human FGF-21 (rhFGF-21) production in …

Tryptophan hydroxylase catalyzes the rate-limiting reaction in the biosynthesis pathway of
serotonin, one of the most ubiquitous and multifunctional neurotransmitters. The influence of …

Abstract Interleukin-33 (IL-33) is one of the important alarmins of the immune system and
possesses dual functions as an anti-or pro-inflammatory molecule. The production of this …

A novel liver-targeting interferon (IFN-CSP) was successfully over-expressed in our previous
work. The in vitro and in vivo investigation revealed that IFN-CSP has significant anti …