Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …

Bioactive peptides are released during the production of fermented dairy, vegetables, fruits,
legumes, fish, and meat products. The proteolytic specificity of lactic acid bacteria, Bacillus …

PHT1 is a histidine/oligopeptide transporter with an essential role in Toll-like receptor innate
immune responses. It can act as a receptor by recruiting the adaptor protein TASL which …

The solute carrier (SLC) family, with more than 400 membrane-bound proteins, facilitates the
transport of a wide array of substrates such as nutrients, ions, metabolites, and drugs across …

High serum urate levels are the major risk factor for gout. URAT1, the primary transporter for
urate absorption in the kidneys, is well known as an anti-hyperuricemia drug target …

Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the
major facilitator superfamily that constitute the main route of entry for a wide range of dietary …

The lysosomal degradation of macromolecules produces diverse small metabolites exported
by specific transporters for reuse in biosynthetic pathways. Here we deorphanized the major …

The uptake and elimination of beta-lactam antibiotics in the human body are facilitated by
the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2). The …

Oxidative stress is recognized to have a central role in the initiation and progression of
Parkinson's disease (PD). Within the brain, neurons are particularly sensitive to oxidation …

Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS)
mediate the uptake of short di-and tripeptides in all phyla of life. POTs are thought to …