Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …

Tight junctions are complex supramolecular entities composed of integral membrane
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …

Statistical analysis of protein evolution suggests a design for natural proteins in which
sparse networks of coevolving amino acids (termed sectors) comprise the essence of three …

Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-
order levels, an organization that guides our current understanding of their biological …

Recent work indicates a general architecture for proteins in which sparse networks of
physically contiguous and coevolving amino acids underlie basic aspects of structure and …

Allosteric drug development holds promise for delivering medicines that are more selective
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …

The internal mechanics of proteins—the coordinated motions of amino acids and the pattern
of forces constraining these motions—connects protein structure to function. Here we …

Proteins mediate transmission of signals along intercellular and intracellular pathways and
between the exterior and the interior of a cell. The dynamic properties of signaling proteins …

Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are
highly enriched in synapses and are responsible for organizing the numerous protein …