GAS5: A pivotal lncRNA in diabetes mellitus pathogenesis and management

KS Alharbi - Pathology-Research and Practice, 2024 - Elsevier
The long non-coding RNA (lncRNA), GAS5, has garnered significant attention recently for its
multifaceted involvement in cellular processes, particularly within the context of diabetes …

The concept of gene therapy for glaucoma: the dream that has not come true yet

R Sulak, X Liu, A Smedowski - Neural regeneration research, 2024 - journals.lww.com
Gene therapies, despite of being a relatively new therapeutic approach, have a potential to
become an important alternative to current treatment strategies in glaucoma. Since …

Micro-RNA profiles of pathology and resilience in posterior cingulate cortex of cognitively intact elders

CM Kelley, B Maloney, JS Beck… - Brain …, 2024 - academic.oup.com
The posterior cingulate cortex (PCC) is a key hub of the default mode network underlying
autobiographical memory retrieval, which falters early in the progression of Alzheimer's …

Unraveling aging from transcriptomics

Y Huang, S Zhu, S Yao, H Zhai, C Liu, JDJ Han - Trends in Genetics, 2024 - cell.com
Research into aging constitutes a pivotal endeavor aimed at elucidating the underlying
biological mechanisms governing aging and age-associated diseases, as well as promoting …

The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence

J Tavares e Silva, J Pessoa, S Nóbrega-Pereira… - Cells, 2024 - mdpi.com
Overcoming senescence with tissue engineering has a promising impact on multiple
diseases. Here, we provide an overview of recent studies in which cellular senescence was …

The role of long noncoding ribonucleic acids in the central nervous system injury

M Huang, X Wang, BOA Botchway, Y Zhang… - Molecular and Cellular …, 2024 - Springer
Central nervous system (CNS) injury involves complex pathophysiological molecular
mechanisms. Long noncoding ribonucleic acids (lncRNAs) are an important form of RNA …

Long Non-Coding RNA Profile in Genetic Symptomatic and Presymptomatic Frontotemporal Dementia: A GENFI Study

M Serpente, C Fenoglio, M Arcaro… - Journal of …, 2024 - content.iospress.com
Background: Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and
are implicated in neurodegenerative diseases, including frontotemporal dementia (FTD) …

Long non-coding RNAs with essential roles in neurodegenerative disorders

W Xiong, L Lu, J Li - Neural Regeneration Research, 2024 - journals.lww.com
Recently, with the advent of high-resolution and high-throughput sequencing technologies,
an increasing number of long non-coding RNAs (lncRNAs) have been found to be involved …

Investigation of Pancreatic-beta Cells Role in the Biological Process of Ageing

R Chaudhary, J Khanna, M Rohilla… - … Metabolic & Immune …, 2024 - ingentaconnect.com
Background: Cellular senescence is associated with the formation and progression of a
range of illnesses, including ageing and metabolic disorders such as diabetes mellitus and …

长链非编码RNA 在神经退行性疾病中的重要作用

W Xiong, L Lu, J Li - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
近年来, 随着高分辨率和高通量测序技术的出现, 越来越多的长链非编码RNA
被发现以特定的时空模式参与中枢神经系统神经元功能的调节, 甚至也参与不同神经退行性疾病 …