Drug delivery through the skin offers many advantages such as avoidance of hepatic first-
pass metabolism, maintenance of steady plasma concentration, safety, and compliance over …

Microneedles (MNs) are minimally invasive devices, which have gained extensive interest
over the past decades in various fields including drug delivery, disease diagnosis …

In recent years, an innovative transdermal delivery technology has attracted great interest for
its ability to distribute therapeutics and cosmeceuticals for several applications, including …

Microneedles were first conceptualized for drug delivery many decades ago, but only
became the subject of significant research starting in the mid-1990's when microfabrication …

Purpose To apply a simple and flexible manufacturing technique, two-photon polymerisation
(2PP), to the fabrication of microneedle (MN) array templates with high precision and low …

The formidable barrier properties of the uppermost layer of the skin, the stratum corneum,
impose significant limitations for successful systemic delivery of broad range of therapeutic …

Many promising therapeutic agents are limited by their inability to reach the systemic
circulation, due to the excellent barrier properties of biological membranes, such as the …

Microfabrication technology has been adapted to produce micron-scale needles as a safer
and painless alternative to hypodermic needle injection, especially for protein …

Dynamic optical coherence elastography is used to determine in vivo skin biomechanical
properties based on mechanical surface wave propagation. Quantitative Young's moduli are …

Microneedles represent a cutting-edge and idea-inspiring technology in biomedical
engineering, which have attracted increasing attention of scientific researchers and medical …