Sialic acid–binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid–
containing ligands and are mainly expressed by cells of the immune system. Many Siglecs …

Mucins are large glycoproteins that are ubiquitous in the animal kingdom. Mucins coat the
surfaces of many cell types and can be secreted to form mucus gels that assume important …

Parasitic diseases affect billions of people and are considered a major public health issue.
Close to 400 species are estimated to parasitize humans, of which around 90 are …

The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which
contribute to parasite protection and to the establishment of a persistent infection. Their …

Oral administration is preferred over other drug delivery methods due to its safety, high
patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Sialic acids are important molecule with high structural diversity. They are known to occur in
higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and …

The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause
important diseases in humans. These include Trypanosoma brucei (the causative agent of …

Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Trypanosoma cruzi expresses at its surface large amounts of mucin-like glycoproteins. The
T. cruzi mucins (TcMUC), a group of highly glycosylated GPI-anchored proteins rich in Thr …