The field of paramagnetic NMR has expanded considerably in recent years. This review
addresses both the theoretical description of paramagnetic NMR, and the way in which it is …

Although scalar-coupling provides important structural information, the resulting signal
splittings significantly reduce the resolution of NMR spectra. Limited resolution is a particular …

The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …

Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …

Abstract α-Synuclein (α-Syn) aggregation is closely associated with Parkinson's disease
neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and …

The synucleins are a family of intrinsically disordered proteins involved in various human
diseases. α‐Synuclein has been extensively characterized due to its role in Parkinson's …

In Parkinson's disease with dementia, up to 50% of patients develop a high number of tau‐
containing neurofibrillary tangles. Tau‐based pathologies may thus act synergistically with …

Adenosine triphosphate (ATP) is an immensely well-studied metabolite serving multiple key
biochemical roles as the major chemical energy currency in living systems, a building block …

Recent advances in NMR methodology and techniques allow the structural investigation of
biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well …

Amelotin is an intrinsically disordered protein (IDP) rich in Pro residues and is involved in
hydroxyapatite mineralization. It rapidly oligomerizes under physiological conditions of pH …