Epigenetic modifications of histones in cancer
Z Zhao, A Shilatifard - Genome biology, 2019 - Springer
The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …
development and disease pathogenesis including human cancers. In this review, we will …
Drug discovery in the era of cryo-electron microscopy
Structure-based drug discovery (SBDD) is an indispensable approach for the design and
optimization of new therapeutic agents. Here, we highlight the rapid progress that has turned …
optimization of new therapeutic agents. Here, we highlight the rapid progress that has turned …
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …
and has been proposed to regulate transcription initiation,. However, redundant functions of …
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
DE Bussiere, L Xie, H Srinivas, W Shu, A Burke… - Nature Chemical …, 2020 - nature.com
The anticancer agent indisulam inhibits cell proliferation by causing degradation of RBM39,
an essential mRNA splicing factor. Indisulam promotes an interaction between RBM39 and …
an essential mRNA splicing factor. Indisulam promotes an interaction between RBM39 and …
Mechanism of cross-talk between H2B ubiquitination and H3 methylation by Dot1L
Methylation of histone H3 K79 by Dot1L is a hallmark of actively transcribed genes that
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
Structural basis of nucleosome recognition and modification by MLL methyltransferases
H Xue, T Yao, M Cao, G Zhu, Y Li, G Yuan, Y Chen… - Nature, 2019 - nature.com
Methyltransferases of the mixed-lineage leukaemia (MLL) family—which include MLL1,
MLL2, MLL3, MLL4, SET1A and SET1B—implement methylation of histone H3 on lysine 4 …
MLL2, MLL3, MLL4, SET1A and SET1B—implement methylation of histone H3 on lysine 4 …
Histone modifications and their regulatory roles in plant development and environmental memory
T Zhao, Z Zhan, D Jiang - Journal of genetics and genomics, 2019 - Elsevier
Plants grow in dynamic environments where they receive diverse environmental signals.
Swift and precise control of gene expression is essential for plants to align their …
Swift and precise control of gene expression is essential for plants to align their …
Structural basis of H2B ubiquitination-dependent H3K4 methylation by COMPASS
The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
EJ Worden, X Zhang, C Wolberger - Elife, 2020 - elifesciences.org
Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …
The benefits of cotranslational assembly: a structural perspective
The faithful assembly of protein complexes in space and time is a hallmark of cellular
homeostasis. Complex assembly might be seeded already during translation, if interacting …
homeostasis. Complex assembly might be seeded already during translation, if interacting …