For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …

One approach to elucidating the principles of regeneration is to investigate mechanisms that
regenerate a target organ. Planarian eyes are discrete, visible structures that are …

Schistosomiasis remains a major neglected tropical disease that afflicts over 200 million
people globally. Schistosomes, the aetiological agent of schistosomiasis, are parasitic …

Adult planarians can regenerate the gut, eyes and even a functional brain. Proper identity
and patterning of the newly formed structures require signals that guide and commit their …

Tissue homeostasis and regeneration involve complex cellular changes. The role of rRNA
modification-dependent translational regulation in these processes remains largely …

Advances in stem cell biology have posed the challenges in revealing the mechanistic
themes underlying whole tissues and organs formation during regeneration. The planarian …

Planarians have a remarkable ability to undergo whole-body regeneration. Successful
regeneration outcome is determined by processes like polarity establishment at the wound …

Studies on transcription regulation in platyhelminth development are scarce, especially for
parasitic flatworms. Here, we employed single-cell transcriptomics to identify genes involved …

Cell types evolve into a hierarchy with related types grouped into families. How cell type
diversification is constrained by the stable separation between families over vast …

As a member of TALE family, Meis1 has been proven to regulate cell proliferation and
differentiation during cell fate commitment; however, the mechanism is still not fully …