[HTML][HTML] Biochemical and structural basis of sialic acid utilization by gut microbes

A Bell, E Severi, CD Owen, D Latousakis… - Journal of Biological …, 2023 - ASBMB
The human gastrointestinal (GI) tract harbors diverse microbial communities collectively
known as the gut microbiota that exert a profound impact on human health and disease. The …

[HTML][HTML] SARS-CoV-2 evolutionary adaptation toward host entry and recognition of receptor O-Acetyl sialylation in virus–host interaction

CH Kim - International journal of molecular sciences, 2020 - mdpi.com
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus
disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into …

Comprehensive characterization of N-and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2

A Shajahan, S Archer-Hartmann, NT Supekar… - …, 2021 - academic.oup.com
The emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created the need for …

The barrier and beyond: Roles of intestinal mucus and mucin-type O-glycosylation in resistance and tolerance defense strategies guiding host-microbe symbiosis

K Bergstrom, L Xia - Gut Microbes, 2022 - Taylor & Francis
Over the past two decades, our appreciation of the gut mucus has moved from a static
lubricant to a dynamic and essential component of the gut ecosystem that not only mediates …

[HTML][HTML] Immunopathology of galectin-3: an increasingly promising target in COVID-19

JL Caniglia, S Asuthkar, AJ Tsung, MR Guda… - …, 2020 - ncbi.nlm.nih.gov
The pandemic brought on by the outbreak of severe acute respiratory syndrome coronavirus
2 (SARS-CoV2) has become a global health crisis, with over 22 million confirmed cases and …

[HTML][HTML] Sialic acid O-acetylation: From biosynthesis to roles in health and disease

EA Visser, SJ Moons, SBPE Timmermans… - Journal of Biological …, 2021 - ASBMB
Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of
vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon …

[HTML][HTML] A potential role for Galectin-3 inhibitors in the treatment of COVID-19

JL Caniglia, MR Guda, S Asuthkar, AJ Tsung… - PeerJ, 2020 - peerj.com
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the
causative agent of coronavirus disease 2019 (COVID-19), has been declared a global …

[HTML][HTML] Mechanism of virus attenuation by codon pair deoptimization

N Groenke, J Trimpert, S Merz, AM Conradie, E Wyler… - Cell reports, 2020 - cell.com
Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that
leads to attenuation is unknown. The strategy involves synthetic recoding of viral genomes …

The glycan-binding trait of the sarbecovirus spike N-terminal domain reveals an evolutionary footprint

H Guo, A Li, HF Lin, MQ Liu, J Chen, TT Jiang… - Journal of …, 2022 - Am Soc Microbiol
The spike protein on sarbecovirus virions contains two external, protruding domains: an N-
terminal domain (NTD) with unclear function and a C-terminal domain (CTD) that binds the …

Influenza D virus utilizes both 9-O-acetylated N-acetylneuraminic and 9-O-acetylated N-glycolylneuraminic acids as functional entry receptors

T Uprety, J Yu, A Nogales, A Naveed, H Yu… - Journal of …, 2024 - Am Soc Microbiol
Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to
other hosts. We have previously demonstrated that IDV binds both 9-O-acetylated N …