Chagas disease is caused by the parasite Trypanosoma cruzi. It is a common cause of heart
disease in endemic areas of Latin America. The year 2009 marks the 100th anniversary of …

Heart failure is a major disease burden worldwide, and its incidence continues to increase
as premature deaths from other cardiovascular conditions decline. Although the overall …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Mutations in LMNA, which encodes nuclear Lamins A and C cause diseases affecting
various organs, including the heart. We have determined the effects of an Lmna H222P …

Chronic Chagas' disease cardiomyopathy is a leading cause of congestive heart failure in
Latin America, affecting more than 3 million people. Chagas' cardiomyopathy is more …

Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in
Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy …

Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …

There is growing evidence to suggest that chagasic myocardia are exposed to sustained
oxidative stress induced injuries that may contribute to disease progression. Trypanosoma …

Chagas disease (CD) is one of the most important neglected tropical diseases in the
American continent. Host‐derived nitroxidative stress in response to Trypanosoma cruzi …

Different studies have illustrated the activation of the innate immune system during infection
with protozoan parasites. Experiments performed in vivo also support the notion that innate …