Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

The rapid detection of microbial agents is essential for the effective initiation of host defence
mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger …

Cerebral small vessel disease (CSVD) is the most common, chronic and progressive
vascular disease. The changes affect arterioles, capillaries and small veins supplying the …

Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve leads
to frequent telomere fusions. The resulting dicentric chromosomes have been proposed to …

TREX1 is an exonuclease that digests DNA in the cytoplasm. Loss-of-function mutations of
TREX1 are linked to Aicardi–Goutieres Syndrome (AGS) and systemic lupus erythematosus …

Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …

Summary Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for the
immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA …

The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …