Diverse mechanisms of antimicrobial activities of lactoferrins, lactoferricins, and other lactoferrin-derived peptides

Š Gruden, N Poklar Ulrih - International journal of molecular sciences, 2021 - mdpi.com
Lactoferrins are an iron-binding glycoprotein that have important protective roles in the
mammalian body through their numerous functions, which include antimicrobial, antitumor …

Lactoferrin in a context of inflammation-induced pathology

ML Kruzel, M Zimecki, JK Actor - Frontiers in immunology, 2017 - frontiersin.org
Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-
binding glycoprotein, in the milieu of immune functionality. This review represents a unique …

Lactoferrin's anti-cancer properties: Safety, selectivity, and wide range of action

A Cutone, L Rosa, G Ianiro, MS Lepanto… - Biomolecules, 2020 - mdpi.com
Despite recent advances in cancer therapy, current treatments, including radiotherapy,
chemotherapy, and immunotherapy, although beneficial, present attendant side effects and …

Lactoferrin from milk: Nutraceutical and pharmacological properties

F Giansanti, G Panella, L Leboffe, G Antonini - Pharmaceuticals, 2016 - mdpi.com
Lactoferrin is an iron-binding protein present in large quantities in colostrum and in breast
milk, in external secretions and in polymorphonuclear leukocytes. Lactoferrin's main function …

Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer's disease

MT Kabir, MS Uddin, S Zaman, Y Begum… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

Occurrence, structure, biochemical properties and technological characteristics of lactoferrin

JM Steijns, ACM Van Hooijdonk - British Journal of Nutrition, 2000 - cambridge.org
The structure of the iron-binding glycoprotein lactoferrin, present in milk and other exocrine
secretions, has been elucidated in great detail, both the three-dimensional protein structure …

Milk biologically active components as nutraceuticals

S Séverin, X Wenshui - Critical reviews in food science and …, 2005 - Taylor & Francis
Milk contains components that provide critical nutritive elements, immunological protection,
and biologically active substances to both neonates and adults. Milk proteins are currently …

Biometal dyshomeostasis and toxic metal accumulations in the development of Alzheimer's disease

Y Li, Q Jiao, H Xu, X Du, L Shi, F Jia… - Frontiers in molecular …, 2017 - frontiersin.org
Biometal dyshomeostasis and toxic metal accumulation are common features in many
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and …

Monoclonal human natural antibodies

TC Rodman - US Patent 7,189,826, 2007 - Google Patents
Disclosed herein are hydridoma cell lines producing mono clonal human natural IgM
antibodies and methods of use thereof. The antibodies are the monoclonal equivalents of …

Role of lactoferrin in the tear film

JL Flanagan, MDP Willcox - Biochimie, 2009 - Elsevier
The surface of the eye provides an inert barrier against infection. Through its unique
combination of antimicrobial action and anti-inflammatory activities lactoferrin (Lf) in the tear …