Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

JJ Rennick, APR Johnston, RG Parton - Nature nanotechnology, 2021 - nature.com
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Endocytosis in cancer and cancer therapy

B Banushi, SR Joseph, B Lum, JJ Lee… - Nature Reviews …, 2023 - nature.com
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

The uptake of metal–organic frameworks: A journey into the cell

E Linnane, S Haddad, F Melle, Z Mei… - Chemical Society …, 2022 - pubs.rsc.org
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …

Carriers break barriers in drug delivery: endocytosis and endosomal escape of gene delivery vectors

IMS Degors, C Wang, ZU Rehman… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …

Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer

CL Chiang, Y Ma, YC Hou, J Pan, SY Chen… - Nature …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and
respond poorly to treatments. There is currently an unmet need for drug carriers that can …

[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles

L Peruzzotti-Jametti, JD Bernstock, CM Willis… - PLoS …, 2021 - journals.plos.org
Neural stem cell (NSC) transplantation induces recovery in animal models of central
nervous system (CNS) diseases. Although the replacement of lost endogenous cells was …

Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing

OO Glebov - The FEBS journal, 2020 - Wiley Online Library
The quest for the effective treatment against coronavirus disease 2019 pneumonia caused
by the severe acute respiratory syndrome (SARS)‐coronavirus 2 (CoV‐2) coronavirus is …

Search for inhibitors of endocytosis: Intended specificity and unintended consequences

D Dutta, JG Donaldson - Cellular logistics, 2012 - Taylor & Francis
We discuss here the variety of approaches that have been taken to inhibit different forms of
endocytosis. Typically, both non-specific and specific chemical inhibitors of endocytosis are …

Entry of human coronavirus NL63 into the cell

A Milewska, P Nowak, K Owczarek… - Journal of …, 2018 - Am Soc Microbiol
The first steps of human coronavirus NL63 (HCoV-NL63) infection were previously
described. The virus binds to target cells by use of heparan sulfate proteoglycans and …