Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor
1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan …

The dentate gyrus, a “gate” that controls the flow of information into the hippocampus, is
critical for learning, memory, spatial navigation, and mood regulation. Several lines of …

Background and Purpose Sleep deprivation compromises learning and memory in both
humans and animals, and can be reversed by administration of modafinil, a drug promoting …

Recent genome-wide association studies on major depressive disorder have implicated
neuronal growth regulator 1 (Negr1), a GPI-anchored cell adhesion molecule in the …

Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …

Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions
including mood, learning and memory. However, mechanisms underlying neural …

Background Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an
essential role in selectively retrieval of transmembrane proteins from endosomes to trans …

Abstract Vps35 (vacuolar protein sorting 35) is a key component of retromer that regulates
transmembrane protein trafficking. Dysfunctional Vps35 is a risk factor for …

Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …

Astrocytes have multiple functions in the brain, including affecting blood vessel (BV)
homeostasis and function. However, the underlying mechanisms remain elusive. Here, we …