Changes in the actin cytoskeleton are a primary mechanism mediating the morphological
and functional plasticity that underlies learning and memory. The synaptic Ras homologous …

Blood vessels demonstrate a multitude of complex signaling programs that work in concert
to produce functional vasculature networks during development. A known, but less widely …

Pathogenic LRRK2 expression causes endolysosomal trafficking alterations by impairing
RAB10 function, and these alterations are rescued by RAB29 independent of its Golgi …

TRIO encodes a cytoskeletal regulatory protein with three catalytic domains—two guanine
exchange factor (GEF) domains, GEF1 and GEF2, and a kinase domain—as well as several …

Small Ras homologous guanosine triphosphatase (Rho GTPase) family proteins are highly
associated with tumorigenesis and development. As intrinsic exchange activity regulators of …

As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases
coordinate a wide range of biological processes such as cell adhesion, motility, and polarity …

The well-studied members of the Trio family of proteins are Trio and kalirin in vertebrates,
UNC-73 in Caenorhabditis elegans and Trio in Drosophila. Trio proteins are key regulators …

Recessive and de novo mutations in the TRIO gene are associated with intellectual
deficiency (ID), autism spectrum disorder (ASD) and developmental epileptic …

The use of cell-penetrating peptides (CPPs), typically HIV-Tat, to deliver therapeutic genes
for cancer treatment is hampered by the inefficient delivery and complicated uptake route of …

Trio is a unique member of the Rho-GEF family that has three catalytic domains and is vital
for various cellular processes in both physiological and developmental settings. TRIO …