Simple Summary ACSL4 is an enzyme involved in the intracellular conversion of long-chain
fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various …

As an iron-dependent regulated form of cell death, ferroptosis is characterized by iron-
dependent lipid peroxidation and has been implicated in the occurrence and development …

Ferroptosis is an oxidative form of iron-dependent cell death characterized by the
accumulation of lipid peroxides on membranes. Iron and lipids containing polyunsaturated …

Background Alzheimer's disease (AD) is a neurodegenerative disease whose origins have
not been universally accepted. Numerous studies have demonstrated the relationship …

Background Recent genome-wide association studies on major depressive disorder (MDD)
have indicated the involvement of LRFN5 and OLFM4; however, the expression levels and …

Central neurological disorders are significant contributors to morbidity, mortality, and long-
term disability globally in modern society. These encompass neurodegenerative diseases …

Alzheimer's disease (AD) is a neurodegenerative disease where abnormal amyloidogenic
processing of amyloid‐β precursor protein (APP) occurs and has been linked to neuronal …

Background Oral submucous fibrosis (OSF) is a precancerous lesion characterized by
fibrous tissue deposition, the incidence of which correlates positively with the frequency of …

Intermittent fasting (IF) is a widely used dietary strategy that has shown several
advantageous impacts on general health and aging. IF has recently been linked to the …

Lactate in the brain is produced endogenously and exogenously. The primary functional
cells that produce lactate in the brain are astrocytes. Astrocytes release lactate to act on …