Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular
responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene …

Abstract Context Polygonum cuspidatum Sieb. et Zucc (Polygonaceae), the root of which is
included in the Chinese Pharmcopoeia under the name 'Huzhang', has a long history as a …

The aim of cancer chemoprevention is disruption or delay of the molecular pathways that
lead to carcinogenesis. Chemopreventive blocking and/or suppressing agents disrupt the …

Aberrant activations of the STAT3 (signal transducer and activator of transcription 3)
signaling pathway are associated with cancer and inflammatory diseases. Three of the four …

Cancers derive from step by step processes which are differentiated by the progressively
accumulated mutations. For some tumors there is a clear progressive advancement from …

Background. Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal
malignancies worldwide. The JAK/STAT signaling pathway is involved in pancreatic cancer …

Tumor metastases that impede the function of vital organs are a major cause of cancer
related mortality. Mitochondrial oxidative stress induced by hypoxia, low nutrient levels, or …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways,
especially the JAK2/STAT3 pathway, play vital roles in the development of many …

Background Signal transducer and activator of transcription 3 (STAT3) is an oncogene
constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells …

Medicinal plants are vital sources of modern and traditional Chinese medicines.
Sesquiterpene lactones (SLs) consist of a large group of plant secondary metabolites and …